Key highlights of the Oncomine Comprehensive Assay Plus
Key highlights of the Oncomine Comprehensive Assay Plus
- Profile 500+ unique genes for single gene and multiple gene biomarker insights
- Detect single gene biomarkers from all variant types including SNVs, indels, CNVs, known and novel fusions, and splice variants
- Analyze complex multi-gene biomarkers for mutational signatures, including tumour mutational burden (TMB) microsatellite instability (MSI) for immunotherapy research
- Detect deficiencies in homology recombination repair (HRR) by assessing variants in 42 HRR pathway genes and genomic instability with sample level loss of heterozygosity (LOH)
- Detect complex loss of function variants (including gene-level LOH) in key HRR genes, including BRCA1 and BRCA2
| Oncomine Comprehensive Plus Assay/Gene list(N=233) | ||||||||||
| Hot Spot Genes | CNV Gain Genes | Copy Number Variation and Hotspot Genes | Gene Fusions (Inter- and Intra-genic) | |||||||
| ACVR1 | NTRK2 | GLI1 | ABCB1 | ABL1 | H3-3A | PIK3R2 | CDK4 | MAX | AKT1 | MYB |
| ATP1A1 | NUP93 | GNA11 | CTNND2 | ABL2 | H3-3B | PIM1 | CDK6 | MDM4 | AKT2 | MYBL1 |
| BCR | PAX5 | GNAQ | DDR1 | AKT1 | IDH2 | PLCG1 | CHD4 | MECOM | AKT3 | NOTCH1 |
| BMP5 | PIK3CD | H2BC5 | EMSY | AKT2 | IKBKB | PPP2R1A | DDR2 | MEF2B | ALK | NOTCH2 |
| BTK | PIK3CG | H3C2 | FGF19 | AKT3 | IL7R | PPP6C | EGFR | MET | AR | NOTCH3 |
| CACNA1D | PTPRD | HIF1A | FGF23 | ALK | KDR | PRKACA | EIF1AX | MITF | BRAF | NRG1 |
| CD79B | RGS7 | HRAS | FGF3 | AR | KIT | PTPN11 | ERBB2 | MPL | BRCA1 | NTRK1 |
| CSF1R | RHOA | IDH1 | FGF4 | ARAF | KLF5 | PXDNL | ERBB3 | MTOR | CDKN2A | NTRK2 |
| CTNNB1 | RPL10 | IL6ST | FGF9 | AURKA | KRAS | RAC1 | ERBB4 | MYC | EGFR | NTRK3 |
| CUL1 | SIX1 | IRF4 | FYN | AURKC | MAGOH | RAF1 | ESR1 | MYCN | ERBB2 | NUTM1 |
| CYSLTR2 | SIX2 | IRS4 | GLI3 | AXL | MAP2K1 | RARA | EZH2 | MYD88 | ERBB4 | PIK3CA |
| DGCR8 | SNCAIP | KLF4 | IGF1R | BCL2 | MAPK1 | RET | FAM135B | NFE2L2 | ERG | PIK3CB |
| DROSHA | SOS1 | KNSTRN | MCL1 | BCL2L12 | TPMT | RHEB | FGFR1 | NRAS | ESR1 | PPARG |
| E2F1 | SOX2 | MAP2K2 | MDM2 | BCL6 | U2AF1 | RICTOR | FGFR2 | NTRK1 | ETV1 | PRKACA |
| EPAS1 | SRSF2 | MED12 | MYCL | BRAF | USP8 | RIT1 | FGFR3 | NTRK3 | ETV4 | PRKACB |
| FGF7 | STAT5B | MYOD1 | RPS6KB1 | CARD11 | XPO1 | ROS1 | FGFR4 | PCBP1 | ETV5 | RAF1 |
| FOXL2 | TAF1 | NSD2 | RPTOR | CBL | ZNF217 | SETBP1 | FLT3 | PDGFRA | FGFR1 | RARA |
| FOXO1 | TGFBR1 | NT5C2 | YAP1 | CCND1 | ZNF429 | SF3B1 | FLT4 | PDGFRB | FGFR2 | RELA |
| TSHR | TRRAP | WAS | YES1 | CCND2 | STAT6 | SLCO1B3 | FOXA1 | PIK3C2B | FGFR3 | RET |
| CCND3 | TERT | SMC1A | GATA2 | PIK3CA | MAP3K8 | ROS1 | ||||
| CCNE1 | TOP1 | SMO | GNAS | PIK3CB | MET | RSPO2 | ||||
| SPOP | SRC | STAT3 | MTAP | RSPO3 | ||||||
| STAT6 | TFE3 | |||||||||
| TERT | TFEB | |||||||||
| YAP1 | ||||||||||
| Oncomine Comprehensive Plus Assay/Gene list-CNV | |||||||
| CNV Loss and CDS (n=206) | CDS Only Genes(n=21) | TMB only genes (n=86) | |||||
| ABRAXAS1 | CDKN2C | FANCM | MUTYH | RAD54L* | CALR | A1CF | OR2T4 |
| ACVR1B | CHEK1* | FAT1 | NBN* | RASA1 | CIITA | ACSM2B | OR2W3 |
| ACVR2A | CHEK2* | FBXW7 | NCOR1 | RASA2 | CYP2D6 | ADAM18 | OR4A15 |
| ADAMTS12 | CIC | FUBP1 | NF1 | RB1 | ERCC5 | ANO4 | OR4C15 |
| ADAMTS2 | CREBBP | GATA3 | NF2 | RBM10 | FAS | ARMC4 | OR4C6 |
| AMER1 | CSMD3 | GNA13 | NOTCH1 | RECQL4 | ID3 | BRINP3 | OR4M1 |
| APC | CTCF | GPS2 | NOTCH2 | RNASEH2A | KLHL13 | C6 | OR4M2 |
| ARHGAP35 | CTLA4 | HDAC2 | NOTCH3 | RNASEH2B | MTUS2 | C8A | OR5D18 |
| ARID1A | CUL3 | HDAC9 | NOTCH4 | RNF43 | PSMB10 | C8B | OR5F1 |
| ARID1B | CUL4A | HLA-A | PALB2* | RPA1 | PSMB8 | CANX | OR5L1 |
| ARID2 | CUL4B | HLA-B | PARP1 | RUNX1 | PSMB9 | CASR | OR5L2 |
| ARID5B | CYLD | HNF1A | PARP2 | SDHA | RNASEH2C | CD163 | OR6F1 |
| ASXL1 | CYP2C9 | INPP4B | PARP3 | SDHB | RPL22 | CNTN6 | OR8H2 |
| ASXL2 | DAXX | JAK1 | PARP4 | SDHD | RPL5 | CNTNAP4 | OR8I2 |
| ATM* | DDX3X | JAK2 | PBRM1 | SETD2 | RUNX1T1 | CNTNAP5 | OR8U1 |
| ATR | DICER1 | JAK3 | PDCD1 | SLX4 | SDHC | COL11A1 | ORC4 |
| ATRX | DNMT3A | KDM5C | PDCD1LG2 | SMAD2 | SOCS1 | DCAF4L2 | PAK5 |
| AXIN1 | DOCK3 | KDM6A | PDIA3 | SMAD4 | STAT1 | DCDC1 | PCDH17 |
| AXIN2 | DPYD | KEAP1 | PGD | SMARCA4 | TMEM132D | GALNT17 | PDE1A |
| B2M | DSC1 | KMT2A | PHF6 | SMARCB1 | UGT1A1 | GPR158 | PDE1C |
| BAP1 | DSC3 | KMT2B | PIK3R1 | SOX9 | ZBTB20 | GRID2 | PLXDC2 |
| BARD1* | ELF3 | KMT2C | PMS1 | SPEN | HCN1 | POM121L12 | |
| BCOR | ENO1 | KMT2D | PMS2 | STAG2 | HLA-C | PPFIA2 | |
| BLM* | EP300 | LARP4B | POLD1* | STK11 | KCND2 | RBP3 | |
| BMPR2 | EPCAM | LATS1 | POLE* | SUFU | KCNH7 | REG1A | |
| BRCA1* | EPHA2 | LATS2 | POT1 | TAP1 | KEL | REG1B | |
| BRCA2* | ERAP1 | MAP2K4 | PPM1D | TAP2 | KIR3DL1 | REG3A | |
| BRIP1* | ERAP2 | MAP2K7 | PPP2R2A* | TBX3 | KRTAP2-1 | REG3G | |
| CASP8 | ERCC2 | MAP3K1 | PRDM1 | TCF7L2 | KRTAP6-2 | RPTN | |
| CBFB | ERCC4 | MAP3K4 | PRDM9 | TET2 | LRRC7 | RUNDC3B | |
| CD274 | ERRFI1 | MAPK8 | PRKAR1A | TGFBR2 | MARCO | SH3RF2 | |
| CD276 | ETV6 | MEN1 | PTCH1 | TNFAIP3 | NLRC5 | SLC15A2 | |
| CDC73 | FANCA | MGA | PTEN* | TNFRSF14 | NOL4 | SLC8A1 | |
| CDH1 | FANCC | MLH1 | PTPRT | TP53* | NRXN1 | SYT10 | |
| CDH10 | FANCD2 | MLH3 | RAD50 | TP63 | NYAP2 | SYT16 | |
| CDK12* | FANCE | MRE11 | RAD51 | TPP2 | OR10G8 | TAPBP | |
| CDKN1A | FANCF | MSH2 | RAD51B* | TSC1 | OR2G6 | TPTE | |
| CDKN1B | FANCG | MSH3 | RAD51C* | TSC2 | OR2L13 | TRHDE | |
| CDKN2A | FANCI | MSH6 | RAD51D* | USP9X | OR2L2 | TRIM48 | |
| CDKN2B | FANCL* | MTAP | RAD52 | VHL | OR2L8 | TRIM51 | |
| ZRSR2 | ZMYM3 | ZFHX3 | XRCC3 | WT1 | OR2M3> | ZIM3> | |
| XRCC2 | OR2T3 | ZNF479 | |||||
| OR2T33 | ZNF536 | ||||||
